英文名称：Propargyl-PEG1-acid
Propargyl-PEG1-COOH
3-Prop-2-ynoxypropanoicacid
分子式：C6H8O3
分子量：128.1
CASNO: 55683-37-9
MDLnumber:MFCD10689189
结构式：
纯度:95%
保存方法:-20°C避光，避湿
产品简介：
Propargyl-PEG1-acidisaheterobifunctional,PEGylatedcrosslinkerfeaturingacarboxylicacidatoneendandpropargylgroupattheotherforreactionwithazide-containingcompoundsusingclickchemistry.ThehydrophillicPEGlinkerfacilitatessolubilityinbiologicalapplications.Propargyl-PEG1-acidcanbeusedforbioconjugationorasabuildingblockforsynthesisofsmallmolecules,conjugatesofsmallmoleculesand/orbiomolecules,orothertoolcompoundsforchemicalbiologyandmedicinalchemistrythatrequireligation.Examplesofapplicationsincludeitssyntheticincorporationintoantibody-drugconjugatesorproteolysis-targetingchimeras(PROTAC?molecules)fortargetedproteindegradation.
Thisisacrosslinkerwithanalkynegroupononeendandacarboxylgroupontheotherend.Thealkynecanbeusedtoattachtoanazideusingcopper-catalyzedclickchemistry.ThecompoundcontainsasinglePEGunittohelpimprovesolubility.
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