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2023-03-23 10:16:22

Phycocyanobilin (Synonyms: 藻青素；藻蓝素)

Phycocyanobilin 是一种具有口服活性的抗氧化剂 (reactive oxygen species)，是一种有效的活性氧清除剂。Phycocyanobilin 可用于阿尔茨海默病的研究。

Phycocyanobilin Chemical Structure


生物活性

Phycocyanobilin, an orally active antioxidative agent, is an effective scavenger for various reactive oxygen species. Phycocyanobilin can be used for the research of Alzheimer’s disease[1][2][3].

体外研究
(In Vitro)

Phycocyanobilin (100 μM; 0-250 min) 抑制亚油酸甲酯的过氧化，并产生较长的诱导期[1]。
Phycocyanobilin (1 mM; 0-300 min) 抑制脂质体的氧化[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Phycocyanobilin (15 mg/kg; p.o.; in diet for 2 weeks) 在 2 型糖尿病小鼠中显示抗氧化作用[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:Male C57BL/Ks J db/db mice, a rodent model for type 2 diabetes[3]Dosage:15 mg/kgAdministration:In diet for 2 weeksResult:Significantly decreased blood glucose levels. Normalized the increases in urinary 8-OHdG and 8-epi-PGF2α levels, renal oxidative stress markers evaluated by renal 8-OHdG staining and DHE staining, Nox4 mRNA, and protein expression, as well as the mRNA levels of other NAD(P)H oxidase components, inflammatory markers and HO-1.

分子量

586.68

性状

Solid

Formula

C33H38N4O6

CAS 号

20298-86-6

中文名称

藻青素；藻蓝素

结构分类

  • Ketones, Aldehydes, Acids

来源

Spirulina platensis

运输条件


储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据

In Vitro: 

DMSO : < 1 mg/mL (ultrasonic;heat to 60°C) (insoluble or slightly soluble)

参考文献


上一篇：AZT triphosphate tetraammonium (Synonyms: 3'-Azido-3'-deoxythymidine-5'-triphosphate tetraammonium)
下一篇：L-Ascorbic acid (Synonyms: L-抗坏血酸; 维生素C; L-Ascorbate; Vitamin C)

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