Quercetin is a type of plant-based chemical, or phytochemical, used as an ingredient in supplements, beverages or foods. In several studies, it may have anti-inflammatory and antioxidant properties, and it is being investigated for a wide range of potential health benefits. Quercetin is a PI3K inhibitor with IC₅₀ of 2.4-5.4 μM. Quercetin strongly abrogates PI3K and Src kinases, mildly inhibits Akt1/2, and slightly affected PKC, p38 and ERK1/2^[1]. Quercetin inhibits TNF-induced LDH% release, EC-dependent neutrophils adhesion to bovine pulmonary artery endothelial cells (BPAEC), and BPAEC DNA synthesis and proliferation^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Combination of Quercetin (75 mg/kg) and 2-Methoxyestradiol enhances inhibition of human prostate cancer LNCaP and PC-3 cells xenograft tumor growth^[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

NCT NumberSponsorConditionStart DatePhaseNCT03943459InCor Heart InstituteCoronary Artery Disease ProgressionAugust 2, 2019Phase 3NCT01732393Mashhad University of Medical SciencesChemotherapy Induced Oral MucositisJanuary 2010Phase 1|Phase 2NCT02652052Mayo ClinicStem Cell TransplantFebruary 19, 2016Not Applicable

302.24

Solid

C₁₅H₁₀O₇

117-39-5

槲皮素；栎精；槲皮黄素

• Flavonoids

• Flavonols

• Plants

• other families

Powder-20°C3 years4°C2 yearsIn solvent-80°C6 months-20°C1 month

In Vitro: 

DMSO : ≥ 100 mg/mL (330.86 mM)

Ethanol : 16.67 mg/mL (55.15 mM; Need ultrasonic)

* "≥" means soluble, but saturation unknown.