DSPE-PEG(2000) Carboxy NHS

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[carboxy(polyethylene glycol)-2000, NHS ester] (sodium salt)

DSPE-PEG (2000) Carboxy NHS is a 1,2-Distearoyl-sn-Glycero-3-Phosphoethanolamine (DSPE) with attached polyethylene glycol (PEG), containing active carboxy N-Hydroxysuccinimide ester (NHS).  It’s a linear heterobifunctional self-assembling reagent to prepare PEGylated liposomes or micelles, while also providing an NHS group for conjugation with amine-containing molecules.

It’s one of the most commonly used reactive phospholipids in targeted drug delivery to modulate the lipid bilayer and thus improve drug solubility. The compound is also often used to conjugate proteins, antibodies, peptides, and other substrates.

As a PEGylated phospholipid, DSPE-PEG (2000) Carboxy NHS has a longer blood circulation time and higher stability and demonstrates amphipathic properties.

Avanti Lipids creates quality DSPE-PEG (2000) Carboxy NHS lab reagent with high purity and excellent chemical reactivity for a range of lipid-oriented studies.

Hygroscopic:No

Light Sensitive:No

Molecular Formula

C₁₃₅H₂₆₀N₂NaO₅₇P

Percent Composition

C 56.35%, H 9.11%, N 0.97%, Na 0.80%, O 31.69%, P 1.08% (average MW due to polydispersity of PEG)

Purity：>99%

Stability：1 Year

Storage Temperature：-20°C

CAS Number：2410279-87-5
CAS Registry Number is a Registered Trademark of the American Chemical Society

Formula Weight：2877.490

Exact Mass：2875.710

Synonyms：1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[acetyl-(polyethylene glycol)-2000 0-(acetylhydroxysuccinimide ester)] (sodium salt)