基本信息：

中文名称：甲氧基聚乙二醇-二苯并环辛烯 (MPEG-DBCO)

别名：MPEG-ADIBO, MPEG-DBCO

英文名称：mPEG-DBCO ; mPEG-Dibenzocycolctyne

CAS：-

分子量：350、500、550、750、1K、2K、5K、10K、20K、30K

纯度：95%以上

MPEG-ADIBO, MPEG-DBCO, 甲氧基PEG二苯并环辛烯

应用简介：

mPEG DBCO, also called methoxy PEG DBCO, is a pegylated DBCO (dibenzocyclooctyne) derivative that can react with azide group without need any metal catalyst. The strain-promoted 1,3-dipolar cycloaddition of cyclooctynes and azides, also termed as the Cu-free Click reaction, is a bioorthogaonal reaction that enables the conjugation of two molecules in aqueous solution. PEG DBCO derivatives have excellent water solubility, possess fast kinetics and stability in aqueous buffer. They are one of the best pegylation reagents to modify proteins, peptides, antibodies,biopolymers and particles via copper free Click Chemistry reaction.

Copper-free Click reaction procedures:

Prepare the azide-containing reagents in reaction buffer.

Add PEG DBCO reagents to azide containing reagents. Add 1 mol equivalent of limiting reagent to 1.5~3.0 mol equivalents of abundance reagent.

Incubate the reaction at room temperature for 2~4 hours or 2~12 hours at 4℃.

Purify conjugates either by dialysis or size-exclusion chromatograph.

MPEG-ADIBO, MPEG-DBCO, 甲氧基PEG二苯并环辛烯

物理性质：

状态：淡黄色到白色固体，或者半固体，取决于分子量。

溶解性：溶于水，乙醇，DMSO等溶剂。

保持条件：-20℃长期保存，避光，干燥。

注意事项：取用一定要干燥，避免频繁的溶解和冻干。

反应性：DBCO与含有N3基团的化合物反应。

技术指标：

纯度（PEG）：95%以上

取代率（DBCO）：95%以上

分散系数（PDI）：小于等于1.05

分析：COA、GPC、NMR、MALDI-TOF

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MPEG-ADIBO, MPEG-DBCO, 甲氧基PEG二苯并环辛烯，德尔塔生物专业供应。