产品名称：14（15）-EpETE
英文名称：14(15)-EpETE
英文别名：(±)14,15 EEQ; (±)14,15-epoxy Eicosatetraenoic Acid
规格或纯度：A solution in ethanol
运输条件：超低温冰袋运输
EDHF（内皮源性超极化因子）是一种响应于乙酰胆碱和缓激肽而从血管内皮细胞释放的未知介质，它不同于NOS-（一氧化氮）和COX衍生（前列环素）的血管扩张剂。CYP450多不饱和脂肪酸的代谢会产生环氧化物，例如14（15）-EpETrE，它们是实际活性介体的主要候选物。然而，相对于花生四烯酸环氧酶代谢产物，对二十碳五烯酸（EPA）和二十二碳六烯酸（DHA）的CYP450代谢产物的研究很少。14（15）-EpETE是14（15）-EpETrE的ω-3同源物，通过EPA的14,15-双键的环氧化获得。尚未确定1
EDHF (endothelium-derived hyperpolarizing factor), an unidentified mediator released from vascular endothelial cells in response to acetylcholine and bradykinin, is distinct from the NOS- (nitric oxide) and COX-derived (prostacyclin) vasodilators. CYP450 metabolism of polyunsaturated fatty acids produces epoxides such as 14(15)-EpETrE which are prime candidates for the actual active mediator. However, the CYP450 metabolites of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have been little studied relative to arachidonate epoxygenase metabolites. 14(15)-EpETE is the ω-3 homolog of 14(15)-EpETrE, derived via epoxidation of the 14,15-double bond of EPA. The EDHF activity of 14(15)-EpETE has not yet been determined.
CAS编号：131339-24-7
折光率：n20D1.51 (Predicted)
沸点：78° C
溶解性：Soluble in water (1 mg/ml at 25° C), PBS (pH 7.2) (~1 mg/ml), DMSO (~50 mg/ml), DMF (~50 mg/ml), and ethanol.
储存温度-20°C储存
分子量：318.5
分子式：C₂₀H₃₀O₃
Smiles：CC/C=C\\\\C[C@H]1O[C@H]1C/C=C\\\\C/C=C\\\\C/C=C\\\\CCCC(=O)O
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