产品名称：鞘磷脂（来自牛脑）
英文名称：Sphingomyelin (from bovine brain)
英文别名：N-Acyl-4-sphingenyl-1-O-phosphorylcholine;N-Acyl-D-sphingosine-1-phosphocholine
规格或纯度：≥98%
运输条件：超低温冰袋运输
鞘磷脂主要包含硬脂酸和神经酸。鞘磷脂在结构上具有神经酰胺核心和通过酰胺键与脂肪酸结合的鞘氨醇。该化合物在顺式/中间-高尔基体中合成，并且通过鞘磷脂酶的作用是神经酰胺第二信使的前体。发现这在信号转导中起作用。细胞的质膜高度富含鞘磷脂（SPH），被认为主要存在于细胞膜的胞质小叶中。已经证实鞘磷脂向细胞表面的运输独立于大鼠肝细胞中的蛋白质分泌而发生。已经观察到，鞘磷脂是在PC12细胞表面上神经节苷脂结合的淀粉样β蛋白生成的关键分子。
Sphingomyelin contains primarily stearic and nervonic acids. Structurally Sphingomyelin has a ceramide core and a sphingosine bonded to a fatty acid via an amide linkage. The compound is synthesized in the cis/medial-Golgi and is a precursor to ceramide second messengers via the action of sphingomyelinase. This is found to have a function in signal transduction. The plasma membrane of cells is highly enriched in sphingomyelin (SPH) and is considered largely to be found in the exoplasmic leaflet of the cell membrane. Transport of sphingomyelin to the cell surface has been demonstrated to occur independent of protein secretion in rat hepatocytes. It has been observed that sphyngomyelin is a key molecule for ganglioside-bound amyloid β-protein generation on the surface of PC12 cells.
CAS编号：85187-10-6
pKa值
pKa: 1.24
溶解性：Soluble in ethanol, chloroform, and Acetic Acid .
储存温度-20°C储存
分子量：731.08
分子式：C41H83N2O6P
EC号：286-097-2
Smiles：CCCCCCCCCCCCCCCCCC(=O)N[C@@H](COP(=O)([O-])OCC[N+](C)(C)C)[C@@H](/C=C/CCCCCCCCCCCCC)O
PubChem CID：6453725
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