产品名称：碳环血氧烷A2
英文名称：Carbocyclic Thromboxane A2
英文别名：Carbocyclic TXA2; CTA2
规格或纯度：A solution in ethanol
运输条件：超低温冰袋运输
碳环血氧烷A2（CTA2）是TXA2的稳定类似物，在低浓度时可作为有效的冠状血管收缩剂。与其他血管TP受体激动剂不同，CTA2是前列腺素诱导的血小板凝集（特别是花生四烯酸诱导的凝集（IC | 50 | = 4-5 µM））的有效抑制剂。在1至100 µM的浓度下，CTA2在兔血小板中还表现出TXB2合成的剂量依赖性和选择性抑制作用。
Carbocyclic Thromboxane A2(CTA2) is a stable analog of TXA2 which acts as a potent coronary vasoconstrictor at low concentrations. Unlike other vascular TP receptor agonists, CTA2 is a potent inhibitor of prostanoid-induced platelet aggregation, specifically arachidonic acid-induced aggregation (IC|50|= 4-5 μM). CTA2 also exhibits dose-dependent and selective inhibition of TXB2 synthesis in rabbit platelets at concentrations between 1 and 100 μM.
CAS编号：74034-56-3
沸点：78° C
溶解性：Soluble in water (>0.1 mg/ml at 25.0° C), DMSO (~25 mg/ml), DMF (~25 mg/ml), PBS(pH 7.2) (~0.1 mg/ml), and ethanol.
储存温度-20°C
储存分子量：348.52
分子式：C₂₂H₃₆O₃Smiles
CCCCCC(O)/C=C/[C@H]1CC2CC(C2)C1C/C=C\\\\CCCC(=O)O
IC50
ArachidonIC₅₀cid-induced aggregation: IC₅₀= 4-5 μM
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