产品名称：（±）-盐酸氯吡格雷
英文名称：(±)-Clopidogrel hydrochloride
英文别名：Plavix; Methyl 2-(4,5,6,7-tetrahydrothieno[3,2-c]pyridin-5-yl)-2-(2-chlorophenyl)acetate hydrochloride
运输条件：冰袋运输
（±）-氯吡格雷盐酸盐是噻吩并吡啶二磷酸腺苷（ADP）-受体拮抗剂。此外，该配体用作选择性不可逆的P2Y12受体拮抗剂。已知P2Y12是位于血小板膜上的ADP受体，负责血小板聚集和血纤蛋白的交联。该机制涉及阻断糖蛋白IIb / IIIa的激活。已知（±）-氯吡格雷盐酸盐通过形成二硫键与ADP受体相互作用。此外，（±）-氯吡格雷盐酸盐被来自肝脏的细胞色素P450酶（特别是CYP2C19）激活。
(±)-Clopidogrel hydrochloride is a thienopyridine adenosine diphosphate (ADP)-receptor antagonist. In addition, this ligand functions as a selective irreversible P2Y12 receptor antagonist. It is known that P2Y12 are ADP receptors located on platelet membranes and are responsible for platelet aggregation and cross-linking by fibrin. This mechanism involves blocking the activation of glycoprotein IIb/IIIa. It is known that (±)-Clopidogrel hydrochloride interacts with the ADP receptor by forming disulfide bonds. Furthermore, (±)-Clopidogrel hydrochloride is activated by cytochrome P450 enzymes from the liver, specifically CYP2C19.
CAS编号：90055-48-4折光率
n20D1.62 (Predicted)
溶解性：Soluble in DMSO (100 mM), ethanol (100 mM), DMF (~20 mg/ml), and DMSO:PBS (1:2, pH 7.2) (~0.33 mg/ml).
储存温度2-8°C储存,干燥分子量：358.28
分子式：C₁₆H₁₆NO₂SCl・HClSmiles
COC(=O)C(C1=CC=CC=C1Cl)N2CCC3=C(C2)C=CS3.Cl
货号：Delta-22386150
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