Rp-8-Br-cGMPS是可渗透细胞的cGMP类似物，可阻断cGMP依赖性蛋白激酶。该化合物已显示出可抑制硝普钠诱导的GT1-7细胞促黄体生成激素释放激素（LHRH）的分泌。使用由去氧肾上腺素收缩的分离的兔主动脉进行的实验表明，Rp-8-Br-cGMPS竞争性抑制8-BR-cGMP引起的松弛。另外，Rp-8-Br-cGMPS在兔子模型中还具有逆转外源性NO增强腹膜中性粒细胞随机迁移的能力。
Rp-8-Br-cGMPS is a cell permeable cGMP analog which blocks cGMP-dependent protein kinase. This compound has been shown to suppress sodium nitroprusside-induced luteinizing hormone-releasing hormone (LHRH) secretion from GT1-7 cells. Experiments using isolated rabbit aorta contracted by phenylephrine have shown that Rp-8-Br-cGMPS competitively inhibits relaxation elicited by 8-BR-cGMP. Additionally Rp-8-Br-cGMPS has displayed the capacity to reverse exogenous NO enhanced random migration of peritoneal neutrophils in rabbit models.
CAS编号：208445-06-1

折光率：n20D1.95 (Predicted)
溶解性：Soluble in water (25 mg/ml).
储存温度：-20°C储存
分子量：462.15
备注：Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.
Smiles
C1[C@@H]2[C@H]([C@H]([C@@H](O2)N3C4=C(C(=O)N=C(N4)N)N=C3Br)O)OP(=S)(O1)[O-].[Na+]
IC50
cyclIC₅₀ucleotide-gated channel: IC₅₀= 173.5 μM
PubChem CID：44755026

Ki Data
PKG: Ki= 4 μM