胍基亚氨基二磷酸是激活ADP-核糖基化因子的优选GTP类似物。鸟嘌呤基亚氨基二磷酸结合并不可逆地激活G蛋白。由于启动GTP结合，水解和释放的周期是启动蛋白质跨内质网转运的必要条件，因此鸟嘌呤基亚氨基二磷酸经常被用于蛋白质合成研究中。鸟嘌呤基亚氨基二磷酸与GTP的不可水解类似物连接。应用鸟苷5′-[β,γ-亚氨基]三磷酸三钠盐水合物用于：研究K-RAS与膜的相互作用，结核分枝杆菌FtsZ结晶作为翻译起始抑制剂，分析48S前起始复合体。GTP的不可水解类似物；用于激活ADP-核糖基化因子的优选GTP类似物。 
Guanylyl Imidodiphosphate is the preferred GTP analog to activate ADP-ribosylation factor. Guanylyl Imidodiphosphate binds and irreversibly activates G proteins. Since a cycle of GTP binding, hydrolysis, and release is required for the initiation of protein translocation across the endoplasmic reticulum, Guanylyl Imidodiphosphate is often used in studies of protein synthesis. Guanylyl Imidodiphosphate has linkage to Non-hydrolyzable analogs of GTP.
CAS编号：148892-91-5
熔点
230° C
溶解性：Soluble in water (50 mg/ml).
储存温度：-80℃储存
分子量：588.14 (anhydrous basis)
分子式：C10H14N6Na3O13P3 · xH2O
备注：Guanylyl Imidodiphosphate is soluble is water, 50 mg/ml
Smiles
C1=NC2=C(N1[C@H]3[C@@H]([C@@H]([C@H](O3)COP(=O)([O-])OP(=O)(NP(=O)(O)[O-])[O-])O)O)NC(=NC2=O)N.[Na+].[Na+].[Na+]
PubChem CID：16219382