CAS:1439488-21-7|CAY10680
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产品别名：
CAY10680
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CAS 号：
1439488-21-7
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分 子 量：
324.4
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分 子 式：
C18H16N2O2S
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产品纯度：
≥95%
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产品规格：
500mg,1g(可根据需求定制)
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运输条件：
顺丰速运包邮
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产品说明：
此产品仅用于科研，不能用于人体治疗、药物开发、和其他商业用途。
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更新时间：
2022-12-04 16:27:58
产品名称：CAY10680
英文名称：CAY10680
英文别名：N-(4-oxo-4H-3,1-benzothiazin-2-yl)-benzenebutanamide
规格或纯度：98%
运输条件：超低温冰袋运输
application：A dual inhibitor of monoamine oxidase B and adenosine A2A receptors.product description：CAY10680 is a dopamine-sparing, benzothiazinone compound that selectively inhibits both MAO-B activity (IC50 = 34.9 nM in human) and adenosine A2A receptors (Ki = 39.5 nM in human). It demonstrates significantly less potent inhibitory values for other adenosine receptor subtypes (Kis > 1 µM) and MAO-A (IC50 ≥ 10 µM). At 1-20 µM, CAY10680 has been shown to abolish cAMP accumulation in CHO cells transfected with adenosine A2A receptors. In the central nervous system adenosine A2A receptor expression is localized to dopamine-innervated areas where heteromeric complexes are formed with dopamine D2 receptors. Because inhibition of adenosine A2A receptors has been shown to enhance D2 receptor function, the blockade of adenosine A2A receptors has emerged as a potential treatment for Parkinson's disease. An additional strategy in the treatment of Parkinson's disease has been to block the activity of monoamine oxidase B (MAO-B), the enzyme involved in dopamine catabolism.
application：A dual inhibitor of monoamine oxidase B and adenosine A2A receptors.product description：CAY10680 is a dopamine-sparing, benzothiazinone compound that selectively inhibits both MAO-B activity (IC50 = 34.9 nM in human) and adenosine A2A receptors (Ki = 39.5 nM in human). It demonstrates significantly less potent inhibitory values for other adenosine receptor subtypes (Kis > 1 µM) and MAO-A (IC50 ≥ 10 µM). At 1-20 µM, CAY10680 has been shown to abolish cAMP accumulation in CHO cells transfected with adenosine A2A receptors. In the central nervous system adenosine A2A receptor expression is localized to dopamine-innervated areas where heteromeric complexes are formed with dopamine D2 receptors. Because inhibition of adenosine A2A receptors has been shown to enhance D2 receptor function, the blockade of adenosine A2A receptors has emerged as a potential treatment for Parkinson's disease. An additional strategy in the treatment of Parkinson's disease has been to block the activity of monoamine oxidase B (MAO-B), the enzyme involved in dopamine catabolism.
CAS编号：1439488-21-7
储存温度-20°C
储存分子量：324.4
分子式：C18H16N2O2S
货号：Delta-71680733
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