产品名称：11-脱氧-11-亚甲基-15-酮基前列腺素D2
英文名称：11-deoxy-11-methylene-15-keto Prostaglandin D2
规格或纯度：A solution in methyl acetate
运输条件：超低温冰袋运输
直接从PGH2衍生的五个主要酶促前列腺素之一。PGD​​2的许多生物学效应是通过经典的7跨膜GPCR DP1受体在体内转导的。但是，第二种受体，即趋化因子相关的CRTH2受体，也与PGD2结合。最近在人类嗜酸性粒细胞上发现了这种新受体，它选择性地结合PGD2代谢产物13,14-dihydro-15-keto PGD2。制备为该受体在化学上更稳定的配体。11-脱氧-11-亚甲基-15-酮PGD2的药理特性尚未发表。
One of the five primary enzymatic prostaglandins derived directly from PGH2. Many of the biological effects of PGD2 are transduced in vivo by a classical 7-transmembrane GPCR, the DP1 receptor. However, a second receptor, the chemokine-related CRTH2 receptor, also binds PGD2. This new receptor was recently identified on human eosinophils, where it binds selectively the PGD2 metabolite 13,14-dihydro-15-keto PGD2. Was prepared as a more chemically stable ligand for this receptor. There are no published studies of the pharmacological properties of 11-deoxy-11-methylene-15-keto PGD2.
CAS编号：958759-75-6

沸点：~525.4° C at 760 mmHg (Predicted)

储存温度-20°C
储存分子量：348.5
分子式：C₂₁H₃₂O₄Smiles
CCCCCC(=O)/C=C/[C@@H]1[C@H]([C@H](CC1=C)O)C/C=C\\CCCC(=O)O
货号：Delta-5283096

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