产品名称：δ17-前列腺素E1
英文名称：δ17-Prostaglandin E1
运输条件：超低温冰袋运输
由ω-3花生四烯酸的COX代谢产生的天然E系列前列腺素。首先将其分离并鉴定为ram精囊微粒体的产物。与PGE2相比，人和其他动物中Δ17-PGE1的相对丰度低，并且很可能反映了磷脂PUFA储库中前体脂肪酸的丰度。关于完整动物中Δ17-PGE1的生物合成的确定性研究尚未完成。作为ADP诱导的兔PRP聚集抑制剂，Δ17-PGE1的效力约为PGE1的一半。在人PRP中，Δ17-PGE1是一种比PGE1更有效的抗血小板激动剂，IC50约为30nM。3尚未报道Δ17-PGE1的血管作用。
A naturally occurring E-series prostaglandin produced by the COX metabolism of ω-3 arachidonic acid. It was first isolated and characterized as a product of ram seminal vesicle microsomes. The relative abundance of Δ17-PGE1 in humans and other animals is low in comparison with PGE2, and is likely to be a reflection of precursor fatty acid abundance in the phospholipid PUFA reservoir. Definitive studies on the biosynthesis of Δ17-PGE1 in intact animals have not been done. Δ17-PGE1 is about half as potent as PGE1 as an inhibitor of ADP-induced aggregation of rabbit PRP. In human PRP, Δ17-PGE1 is a more potent antiplatelet agonist than PGE1, with an IC50 of about 30 nM.3 The vascular effects of Δ17-PGE1 have not been reported.
CAS编号：7046-45-9
储存温度-20°C
储存分子量：352.5
分子式：C₂₀H₃₂O₅Smiles
CCC=CCC(C=CC1C(CC(=O)C1CCCCCCC(=O)O)O)O
货号：Delta-35021455

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